Division of Gastroenterology

Declan McCole, PhD

Declan McCole, PhD

Assistant Adjunct Professor of Medicine

Office Phone: (858) 534-2794
Lab Phone: (858) 534-2791
Email: dmccole@ucsd.edu
Lab Website: mccolelab.ucsd.edu

Research Interests

  • Inflammatory bowel disease
  • Epithelial cell biology
  • Ion transport
  • Barrier function
  • Regulation of epithelial cell function by the energy sensor
  • AMPK

Most Significant Publications

  • McCole DF, Keely SJ, Barrett KE. Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-a. J Biol Chem 2002; 277: 42063-42612.
  • McCole DF, Laurent F, Eckmann L, Kagnoff MF. Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection. Infect Immun 2000; 68: 1710-1713.
  • McCole DF, Rogler G, Varki N, Barrett KE. Epidermal growth factor partially restores colonic ion transport responses in mouse model of chronic colitis. Gastroenterology 2005; 129: 591-608.
  • McCole DF, Truong A, Bunz M, Barrett KE. Consequences of direct vs. indirect activation of EGFr in intestinal epithelial cells are dedicated by protein tyrosine phosphatase 1B. J Biol Chem 2007; 282: 13303-13315.
  • Chappell AE, Bunz M, Dong H, Seol E, Lytle C, Barrett KE, McCole DF. Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins. FASEB J 2008; 22: 2023-2036.

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