Division of Gastroenterology

Alan Hofmann, MD

Professor of Medicine, Emeritus

Dr. Hofmann's laboratory is interested in lipid digestion and absorption in health and disease; nutrient absorption; bile acid evolution, pathobiology, and pathochemistry; bile secretion; cholelithiasis; biliary physiology and pharmacology; diagnosis and treatment of digestive and hepatobiliary disease; enterohepatic circulation of endobiotics and xenobiotics; breath tests in diagnosis; defective bile acid metabolism in pediatric constipation; bile acids as modulators of intestinal bacteria.

Most Significant Publications

  • Hofmann AF and Borgstrom B. The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption. J Clin Invest 1964; 43: 247-257.
  • Hofmann AF and Poley JR. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology 1972; 62: 918-934.
  • LaRusso NF, Korman MG, Hoffman NE, and Hofmann AF. Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. N Engl J Med 1974; 291: 689-692.
  • Hofmann AF, Thisle JL, Klein PD, Szczepanik PA, and Yu PYS. Chenotherapy for gallstones. II. Induced changes in bile composition and gallstone response. JAMA 1978; 239: 1138-1144.
  • Hofmann AF, Molino G, Milanese M, and Belforte G. Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy main. J Clin Invest 1983; 71: 1003-1022.
  • Roda A, Hofmann AF, and Mysels KJ. The influence of bile salt structure on self-association in aqueous solutions. J Biol Chem 1983; 258: 6362-6370.
  • Yoon YB, Hagey LR, Hofmann AF, Gurantz D, Michelotti EL, and Steinbach JH. Effect of side-chain shortening on the physiological properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoycholate in rodents. Gastroenterology 1986; 90: 837-852.
  • Marcus SN, Schteingart CD, Marquez ML, Hofmann AF, Xia Y, Steinbach JH, Ton-Nu H-T, Lillienau J, Angellotti MA, and Schmassmann A. Active absorption of conjugated bile acids in vivo: kinetic parameters and molecular specificity of the ileal transport system in the rat. Gastroenterology 1991; 100: 212-221.

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