Division of Gastroenterology

Ekihiro Seki, MD, PhD

Assistant Professor of Medicine


Office Phone: (858) 822-3347
Office Fax: (858) 822-5370

Lab website: sekilab.ucsd.edu

Research Interests

  • Regulation of innate immune system and inflammation in hepatic fibrosis.
  • Crosstalk between hepatic stellate cells and immune cells including Kupffer cells in liver diseases.
  • Modulation of TGFb signaling by Toll-like receptors in hepatic stellate cells.

Most Significant Publications

  • Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K. Critical roles of myeoloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 2002; 169: 3863-3868.
  • Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology 2005; 41: 443-450.
  • De Minicis S*, Seki E*, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007; 132: 1937-1946. (*equal contribution by 1st & 2nd authors).
  • Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGFb signaling and hepatic fibrosis. Nat Med 2007; 13: 1324-1332.
  • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: Update. Hepatology 2008; 48: 322-335. (Review).