Division of Gastroenterology

Sheila E. Crowe, MD

Professor of Medicine
Director of Research

Administrative Office: (858) 534-2757
To make an appointment with this physician, click here

Research Interests

My research program explores the interaction of luminal contents including microbes with the gastrointestinal mucosa that can lead to inflammatory disease and associated epithelial cancer. I have focused on the role of oxidative stress in modulating host responses to bacteria, antigens and inflammatory processes and examining the multi-functional regulatory protein, AP endonuclease-1 as it regulates epithelial cell responses. Our general approach has been to study signaling events in cultured cell lines and to validate the models using human tissues. As a clinician-scientist, gastroenterologist, I have been active in basic, translational, and clinical research.


 University of Toronto (Trinity College) BSc 1979 Gen Sci/Microbiology
 McMaster University MD 1982 Medicine
 McMaster University Internship   1982-1983 Internal Medicine
 McMaster University     Residency  1983-1986     Internal Medicine
 McMaster University  Fellowship 1986-1988 Gastroenterology

Laboratory Personnel

Victoria Castillo, DVM      Postdoctoral Fellow      vcastillo@ucsd.edu      
Amber Ablack SRA alablack@ucsd.edu     
Bobbie Gomez SRA bagomez@ucsd.edu


See publications for Sheila E. Crowe, MD, click here