Division of Gastroenterology

Sheila E. Crowe, MD

Professor of Medicine
Director of Research

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Direct Clinic Line:
(619) 543-2347

New Patient Registration:
(800) 926-8273 FREE

Administrative Office: (858) 534-2757

Research Interests

My research program explores the interaction of luminal contents including microbes with the gastrointestinal mucosa that can lead to inflammatory disease and associated epithelial cancer. I have focused on the role of oxidative stress in modulating host responses to bacteria, antigens and inflammatory processes and examining the multi-functional regulatory protein, AP endonuclease-1 as it regulates epithelial cell responses. Our general approach has been to study signaling events in cultured cell lines and to validate the models using human tissues. As a clinician-scientist, gastroenterologist, I have been active in basic, translational, and clinical research.


 University of Toronto (Trinity College) BSc 1979 Gen Sci/Microbiology
 McMaster University MD 1982 Medicine
 McMaster University Internship   1982-1983 Internal Medicine
 McMaster University     Residency  1983-1986     Internal Medicine
 McMaster University  Fellowship 1986-1988 Gastroenterology

Laboratory Personnel

Victoria Castillo, DVM      Postdoctoral Fellow      vcastillo@ucsd.edu      
Amber Ablack SRA alablack@ucsd.edu     
Bobbie Gomez SRA bagomez@ucsd.edu


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