Division of Gastroenterology

David A. Brenner, MD

Vice Chancellor, Health SciencesDr. David Brenner
Dean, School of Medicine
Professor of Medicine

Research Interests

David Brenner, MD, a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 2007. In this role, Dr. Brenner leads the UC San Diego School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD Medical Center, and UCSD Medical Group. He has oversight of over 900 faculty physicians, pharmacists and scientists; 7,500 staff; over 600 medical and pharmacy students,
and a health system that cares for approximately 135,000 patients annually.

Dr. Brenner is a leader in the field of gastroenterological research, specializing in diseases of the liver. He is widely respected as a translational scientist whose work bridges the laboratory and clinical settings. He has focused on understanding the molecular pathogenesis of fibrotic liver disease and the genetic basis of liver disorders as the foundation for improving prevention and treatment of liver disease.

Education

Institution                                        Degree        Year         Field of Study

Yale University, New Haven, CT      BS     1975     Biology    
Yale University, New Haven, CT MD 1979 Medicine    
Yale University, New Haven, CT Intern &
Residency    
1982-85     Internal Medicine    
NIH/NIDDK, Bethesda, MD Fellowship 1985-86 Genetics & Biochemistry    
UC San Diego, CA Fellowship 1986-1988     Gastroenterology

Publications

  • Bataller R, Schwabe FR, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003; 112(9): 1383-1394.
  • Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. TRAM2 protein interacts with endoplasmic reticulum CA2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol 2004; 24(4): 1758-1768.
  • Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. Roles for C16-ceramide and sphingosine-1-phosphate in regulating hepatocyte apoptosis in response to TNF-a. J Biol Chem 2005; 280(30): 27879-27887.
  • Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. The forkhead transcription factor Fox01 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 2007; 132(4): 1434-1446.
  • Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-b signaling and hepatic fibrosis. Nat Med 2007; 13(11): 1324-1332.

To see more publications for Dr. Brenner, click here.

Laboratory Personnel

Tatiana Kisseleva, MD, PhD     tkisseleva@ucsd.edu      
Karin Diggle kdiggle@ucsd.edu 
Denise Marlin    dmarlin@ucsd.edu  
Sara Morimoto smorimoto@ucsd.edu